On the agenda on 6 January are talks with Turkey's Foreign Minister Abdullah Gul.
Karzai is meeting Turkish political and military leaders to discuss ways of boosting investment in his country.
Turkish private investors and aid groups in Afghanistan are involved in a range of contracts worth about $1 billion. Most of that work is in the construction sector, building roads, medical clinics and schools.
Karzai met his Turkish counterpart Ahmet Necdet Sezer on 5 January. They later signed an accord aimed at making it easier for Turkish aid to reach Afghanistan.