Gaza police say Israeli airstrikes have leveled a seven-floor office building and severely damaged a two-story commercial building with dozens of shops in the southern town of Rafah.
Police say seven people were wounded by the bombing of the commercial center. There were no reports of casualties from the other strike.
An office of the Hamas-run Interior Ministry was located in the seven-story Zourab building.
Hospital sources said two people were killed and five others injured in another air strike in the western part of Gaza City.
The strikes came a day after Israel toppled a 12-story tower in Gaza City.
Israel says it targeted a Hamas operations room in the apartment tower.
Meanwhile, the Israeli military says five rockets were fired from Syria at the Israeli-annexed Golan Heights, falling in open areas.
Amid signs of further escalation, Egypt has urged both sides to resume indirect cease-fire talks in Cairo.