Today's decision resembles a ruling last month that denied asylum to two other Uzbeks who were seeking refuge in Kyrgyzstan.
The four are seeking asylum for fear of persecution by authorities in Uzbekistan. Uzbek authorities say they were involved in last year's Andijon unrest.
The four face extradition, but could possibly be sent to a third country.
The UN High Commissioner for Human Rights had previously granted them refugee status, and rights groups fear the four could be tortured if returned to Uzbekistan.
(RFE/RL's Kyrgyz Service)