Mutabar Turgunova told RFE/RL’s Uzbek Service that her husband, Azam, a well-known human rights activist who is serving a 10-year sentence, has had no contact with his lawyer or with her since December.
A vocal human rights activist for more than a decade, Turgunov has defended the rights of political and religious prisoners and protested against the use of torture in Uzbekistan's prisons.
He once told Human Rights Watch that "if everybody stays silent, the situation would get even worse."
In October, he was tried and convicted on charges of extortion.
But since the case was reviewed last month, "neither I nor his lawyer know where he is," Turgunova said.