It will be Yanukovych's first trip to the United States since his party's strong showing in parliamentary elections earlier this year returned him to office.
Yanukovych's office said the prime minister would hold talks with officials including U.S. Vice President Dick Cheney and Secretary of State Condoleezza Rice in meetings starting on December 4.
No meeting with U.S President George W. Bush has been announced.
The U.S. State Department said it expected that the talks between Yanukovych and U.S. officials would touch on Ukraine's relations with NATO and the European Union, as well as Ukraine's economic reforms.
Yanukovych, who is expected to attend an economic forum in New York later this week, will also try to advance Ukraine's bid to join the World Trade Organization.
Reports said he may also seek to assure U.S. leaders that he supports democratization and reform in Ukraine.
Yanukovych met with Russian President Vladimir Putin in Moscow on November 30.
A worker inspects a gas facility outside of Kyiv (epa file photo)
MURKY CONNECTIONS. A year after the so-called gas war between Moscow and Kyiv, energy transhipments from Russia to Europe via Ukraine remain a concern. On December 1, RFE/RL's Washington office hosted a briefing featuring Tom Mayne, an energy researcher for the London-based Global Witness. Mayne discussed the lack of transparency in the energy sectors of Ukraine, Russia, and gas supplier Turkmenistan.
LISTENListen to the entire briefing (about 60 minutes):
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